Distinct specifity of lymphocytotoxic antibodies in autoimmune disease

Lymphocytotoxic antibodies in systemic lupus

The lymphocytotoxicity of 33 lupus sera was tested against purified helper/inducer (OKT4) and cytotoxic/suppressor (OKT8) subsets of T lymphocytes at 15°C and 37°C in vitro. There was significantly less killing of both OKT4 and OKT8 cells at 37°C (p<0001 and p<0-01) and the ratio of OKT4/OKT8 cell killing at 15°C (1-39 (0.73); mean (SD)) was different from that observed at 37°C (0.79 (0.42)) (p...

Incidence and Correlation with Lymphocytotoxic Antibodies

The anti-RNA antibodies were present in consanguineous household contacts but not in nonconsanguineous household contacts. These findings strengthen the hypothesis that both an environmental agent, possibly a virus, as well as the genetic response are important in the pathogenesis of SLE. Family members may therefore be a logical population in whom to search for specific antibodies to a viral a...

Autoimmune Kidney Disease: Distinct Roles

Increased frequency of lymphocytotoxic antibodies in patients with multiple sclerosis correlated with disease activity.

Cold-reactive lymphocytotoxic antibodies (LCA) were investigated in sera from patients with multiple sclerosis (MS) in relation to disease activity. When a serum with more than 20% cytotoxicity is considered positive for the presence of LCA, the positive frequency at remission was 21% (6/28), but at exacerbation it was 83% (10/12). All the sera from normal controls were negative. The average of...

Lymphocytotoxic antibodies in systemic lupus erythematosus: their clinical significance.

Cold-reactive lymphocytotoxic antibodies are present in the serum of most patients with systemic lupus erythematosus (SLE) (Mittal et al., 1970; Terasaki et al., 1970). They appear to be equally cytotoxic for autologous and heterologous lymphocytes (Stastny and Ziff, 1971). Studies of the nature of these antibodies showed that their cytotoxic effect is temperature-dependent and maximal at 15°C,...